Xenobiotic-Metabolizing Enzymes in Skeletal Muscle of Children and Adolescents
نویسندگان
چکیده
منابع مشابه
Polymorphisms of xenobiotic-metabolizing enzymes and susceptibility to cancer.
The variation in individual responses to exogenous agents is exceptionally wide. It is because of this large diversity of responsiveness that risk factors to environmentally induced diseases have been difficult to pinpoint, particularly at low exposure levels. Opportunities now exist for studies of host factors in cancer or other diseases in which an environmental component can be presumed. Man...
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The cytochrome P450 (CYP) enzyme system in human lung is an essential component in the pulmonary carcinogenicity of several inhaled xenobiotic compounds. The aim of this study was to elucidate the expression and regulation of xenobiotic-metabolizing CYP enzymes in human lung. To evaluate which of the two is a better surrogate cell model for lung tissue, the expression patterns of CYP enzymes in...
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15 صفحه اولExpression of Xenobiotic Metabolizing Enzymes in Different Lung Compartments of Smokers and Nonsmokers
BACKGROUND Cytochrome P450 monooxygenases (CYP) play an important role in the defense against inhaled toxicants, and expression of CYP enzymes may differ among various lung cells and tissue compartments. METHODS We studied the effects of tobacco smoke in volunteers and investigated gene expression of 19 CYPs and 3 flavin-containing monooxygenases, as well as isoforms of glutathione S-transfer...
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ژورنال
عنوان ژورنال: Pharmacology & Pharmacy
سال: 2013
ISSN: 2157-9423,2157-9431
DOI: 10.4236/pp.2013.42032